ruleID	organism	gene	nodeID	refseq accession	GenBank accession	HMM accession	ARO accession	mutation	variation type	context	drug	drug class	phenotype	clinical category	breakpoint	breakpoint standard	PMID	evidence code	evidence grade	evidence limitations	rule curation note
YER0023	s__Yersinia enterocolitica	aac(3)-IVa	aac(3)-IVa	-	-	-	-	-	Gene presence detected	acquired	gentamicin	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only for systemic or originating from the urinary tract infections	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Gentamycin resistance.
YER0024	s__Yersinia enterocolitica	aac(3)-IVa	aac(3)-IVa	-	-	-	-	-	Gene presence detected	acquired	tobramycin	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only for systemic or originating from the urinary tract infections	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tobramycin resistance.
YER0043	s__Yersinia enterocolitica	ampC	-	-	CBY26916.1	-	-	-	Gene presence detected	core	cefoxitin	-	wildtype	R	MIC >8 mg/L	"Expected resistant phenotypes v1.2 (13 January, 2023)"	20547799	ECO:0001091 knockout phenotypic evidence	strong		"Wildtype core gene, higher induction of ampC in bioserotype 2/O:9 is expected to confer resistance to 2nd generation cephalosporin, explaining the expected resistant to Cefoxitin"
YER0049	s__Yersinia enterocolitica	aph(3')-IIa	aph(3')-IIa	-	CAA23892.1	-	-	-	Gene presence detected	acquired	kanamycin A	-	nonwildtype	R	Missing in EUCAST breakpoints tables	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		
YER0025	s__Yersinia enterocolitica	aph(4)-Ia	aph(4)-Ia	-	-	-	-	-	Gene presence detected	acquired	gentamicin	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only for systemic or originating from the urinary tract infections	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Gentamycin resistance.
YER0026	s__Yersinia enterocolitica	aph(4)-Ia	aph(4)-Ia	-	-	-	-	-	Gene presence detected	acquired	tobramycin	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only for systemic or originating from the urinary tract infections	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tobramycin resistance.
YER0037	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	-	Gene presence detected	core	amoxicillin	-	wildtype	R	MIC >8 mg/L	"Expected resistant phenotypes v1.2 (13 January, 2023)"	20547799	ECO:0001091 knockout phenotypic evidence	strong		"Wildtype core gene, all blaA alleles are expected to confer resistance to penicillins, explaining the expected resistant to Amoxicillin"
YER0038	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	-	Gene presence detected	core	amoxicillin-clavulanic acid	-	wildtype	R	MIC >8 mg/L	"Expected resistant phenotypes v1.2 (13 January, 2023)"	20547799	ECO:0001091 knockout phenotypic evidence	strong		"Wildtype core gene, all blaA alleles are expected to confer resistance to penicillins, explaining the expected resistant to Amoxicillin-clavulanic acid"
YER0040	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	-	Gene presence detected	core	ampicillin-sulbactam	-	wildtype	S	diameter >14 mm	EUCAST v14.0 (2024)	20547799	ECO:0001103 natural variation mutant evidence	strong		Testing of strains of biotype 2 and 4 resulted in susceptible phenotypes
YER0041	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	-	Gene presence detected	core	cefalexin	-	wildtype	R	not applicable	"Expected resistant phenotypes v1.2 (13 January, 2023)"	20547799	ECO:0001091 knockout phenotypic evidence	strong		"Wildtype core gene, all blaA alleles are expected to confer resistance to 1st generation cephalosporin, explaining the expected resistant to Cefalexin"
YER0039	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	-	Gene presence detected	core	ticarcillin	-	wildtype	R	not applicable	"Expected resistant phenotypes v1.2 (13 January, 2023)"	20547799	ECO:0001091 knockout phenotypic evidence	strong		"Wildtype core gene, all blaA alleles are expected to confer resistance to penicillins, explaining the expected resistant to Ticarcillin"
YER0042	s__Yersinia enterocolitica	blaA	blaA_Yent	-	-	-	-	c.592del_50pb	Nucleotide variant detected	core	ticarcillin	-	wildtype	S	not applicable	"Expected resistant phenotypes v1.2 (13 January, 2023)"	11102414	ECO:0001113 point mutation phenotypic evidence	strong		"Wildtype core gene, mutation (deletion of 50 bp) in blaA leading to premature stop codon, explaining the susecptibility to Ticarcillin (only in bioserotype 2/O:5)"
YER0027	s__Yersinia enterocolitica	blaOXA-48	blaOXA-48	-	-	-	-	-	Gene presence detected	acquired	ertapenem	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Ertapenem resistance.
YER0044	s__Yersinia enterocolitica	blaTEM-181	blaTEM-181	-	-	-	-	-	Gene presence detected	acquired	amoxicillin	-	nonwildtype	R	MIC >8 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Redundant with effect of blaA
YER0028	s__Yersinia enterocolitica	dfrA1	dfrA1	-	-	-	-	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Trimethoprim resistance.
YER0054	s__Yersinia enterocolitica	dfrA12	dfrA12	-	-	-	ARO: 39292	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Trimethoprim resistance.
YER0029	s__Yersinia enterocolitica	dfrA14	dfrA14	-	-	-	-	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Trimethoprim resistance.
YER0030	s__Yersinia enterocolitica	dfrB1	dfrB1	-	-	-	-	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Trimethoprim resistance.
YER0046	s__Yersinia enterocolitica	floR	floR	-	-	-	-	-	Gene presence detected	acquired	chloramphenicol	-	nonwildtype	R	NWT>4 mg/mL	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Chloramphenicolresistance.
YER0014	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Gly81Cys	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0015	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Asp82Ser83Gly	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	-	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0016	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Ser83Ile	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0017	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Ser83Arg	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0018	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Ser83Cys	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0019	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Val85Ile	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0020	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Asp87Gly	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0021	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Asp87Asn	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	15117921	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0022	s__Yersinia enterocolitica	gyrA	-	WP_013650157.1	-	-	-	p.Asp87Tyr	Protein variant detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	12682183	ECO:0000042 gain-of-function mutant phenotypic evidence	moderate		Experimental evidence in Y. enterocolitica showing that this mutation in gyrA is associated with Nalidixic acid resistance.
YER0048	s__Yersinia enterocolitica	qnrB19	qnrB19	-	-	-	-	-	Gene presence detected	acquired	nalidixic acid	-	nonwildtype	R	not applicable	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in other Enterobacterales
YER0053	s__Yersinia enterocolitica	sat2	sat2_fam	-	-	-	ARO:3002895	-	Gene presence detected	acquired	streptothricin	-	nonwildtype	R	Missing in EUCAST breakpoints tables	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		
YER0031	s__Yersinia enterocolitica	sul1	sul1	-	-	-	-	-	Gene presence detected	acquired	sulfamethoxazole	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only in association with Trimethoprim	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Sulfamethoxazole resistance.
YER0032	s__Yersinia enterocolitica	sul2	sul2	-	-	-	-	-	Gene presence detected	acquired	sulfamethoxazole	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only in association with Trimethoprim	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Sulfamethoxazole resistance.
YER0051	s__Yersinia enterocolitica	sul3	sul3	-	-	-	ARO: 3000413	-	Gene presence detected	acquired	sulfamethoxazole	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only in association with Trimethoprim	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Sulfamethoxazole resistance.
YER0033	s__Yersinia enterocolitica	tet(A)	tet(A)	WP_000804064.1	-	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tetracyclin resistance.
YER0034	s__Yersinia enterocolitica	tet(B)	tet(B)	WP_012881330.1	-	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tetracyclin resistance.
YER0035	s__Yersinia enterocolitica	tet(C)	tet(C)	WP_001297013.1	-	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tetracyclin resistance.
YER0036	s__Yersinia enterocolitica	tet(H)	tet(H)	WP_006248867.1	-	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tetracyclin resistance.
YER0052	s__Yersinia enterocolitica	tet(M)	tet(M)	-	-	-	ARO:3000186	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. enterocolitica showing that gene acquisition is associated with Tetracyclin resistance.
YER0050	s__Yersinia enterocolitica	vat(F)	vat(F)	WP_005164767.1	-	-	-	-	Gene presence detected	core	-	streptogramin antibiotic	wildtype	R	Missing in EUCAST breakpoints tables	EUCAST v14.0 (2024)	38176093	ECO:0001103 natural variation mutant evidence	moderate		"78,9% Yersinia enterocolotica chromosomes (CARD)"
YER0002	s__Yersinia pseudotuberculosis	ant(3'')-Ia	ant(3'')-Ia	-	-	-	-	-	Gene presence detected	acquired	streptomycin	-	nonwildtype	R	Missing in EUCAST breakpoint tables	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Streptomycin resistance.
YER0003	s__Yersinia pseudotuberculosis	aph(3'')-Ib	aph(3'')-Ib	-	-	-	-	-	Gene presence detected	acquired	streptomycin	-	nonwildtype	R	Missing in EUCAST breakpoint tables	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Streptomycin resistance.
YER0001	s__Yersinia pseudotuberculosis	aph(6)-Id	aph(6)-Id	-	-	-	-	-	Gene presence detected	acquired	streptomycin	-	nonwildtype	R	Missing in EUCAST breakpoint tables	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Streptomycin resistance.
YER0004	s__Yersinia pseudotuberculosis	blaOXA-2	blaOXA-2	-	-	-	-	-	Gene presence detected	acquired	amoxicillin	-	nonwildtype	R	MIC >8 mg/L	EUCAST v14.0 (2024)	-	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Amoxicillin resistance.
YER0005	s__Yersinia pseudotuberculosis	blaTEM-1	blaTEM-1	AAR25033.1	-	-	-	-	Gene presence detected	acquired	amoxicillin	-	nonwildtype	R	MIC >8 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Amoxicillin resistance.
YER0006	s__Yersinia pseudotuberculosis	blaTEM-1	blaTEM-1	AAR25033.1	-	-	-	-	Gene presence detected	acquired	ticarcillin	-	nonwildtype	R	Missing in EUCAST breakpoint tables	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Ticarcillin resistance.
YER0013	s__Yersinia pseudotuberculosis	catA2	catA2	-	-	-	-	-	Gene presence detected	acquired	chloramphenicol	-	nonwildtype	R	MIC >16 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Chloramphenicolresistance.
YER0007	s__Yersinia pseudotuberculosis	dfrA1	dfrA1	-	-	-	-	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Trimethoprim resistance.
YER0008	s__Yersinia pseudotuberculosis	dfrA14	dfrA14	-	-	-	-	-	Gene presence detected	acquired	trimethoprim	-	nonwildtype	R	MIC >0.5 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Trimethoprim resistance.
YER0009	s__Yersinia pseudotuberculosis	sul1	sul1	-	-	-	-	-	Gene presence detected	acquired	sulfamethoxazole	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only in association with Trimethoprim	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Sulfamethoxazole resistance.
YER0010	s__Yersinia pseudotuberculosis	sul2	sul2	-	-	-	-	-	Gene presence detected	acquired	sulfamethoxazole	-	nonwildtype	R	Missing in EUCAST breakpoint tables - only in association with Trimethoprim	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Sulfamethoxazole resistance.
YER0011	s__Yersinia pseudotuberculosis	tetA(A)	-	-	CAD57192.1	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Tetracyclin resistance.
YER0012	s__Yersinia pseudotuberculosis	tetA(D)	-	-	AAL75563.1	-	-	-	Gene presence detected	acquired	tetracycline	-	nonwildtype	R	MIC >4 mg/L	EUCAST v14.0 (2024)	28830739	ECO:0001103 natural variation mutant evidence	moderate		Experimental evidence in Y. pseudotuberculosis showing that gene acquisition is associated with Tetracyclin resistance.