ruleID organism gene nodeID refseq accession GenBank accession HMM accession ARO accession mutation variation type context drug drug class phenotype clinical category breakpoint breakpoint standard PMID evidence code evidence grade evidence limitations Rule cutation note PSA0019 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core aztreonam - wildtype I MIC <= 16 mg/L EUCAST v14.0 (2024) 9925544 ECO:0001091 knockout phenotypic evidence strong "ampC (blaPDC) derepression occurs by the acquistion of mutations in its major regulators genes: ampD (10681322, 16251318, 16641450), dacB (19325877) and ampR (27736752, 29029112). Leads to acquired resistance" PSA0023 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) 11083635 ECO:0001091 knockout phenotypic evidence strong "ampC (blaPDC) derepression occurs by the acquistion of mutations in its major regulators genes: ampD (10681322, 16251318, 16641450), dacB (19325877) and ampR (27736752, 29029112). Leads to acquired resistance" PSA0033 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ceftazidime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "9925544, 3493236" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) derepression occurs by the acquistion of mutations in its major regulators genes: ampD (10681322, 16251318, 16641450), dacB (19325877) and ampR (27736752, 29029112). Leads to acquired resistance" PSA0072 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core piperacillin - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "9925544, 3493236, 2158496, 2159863" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0076 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core piperacillin-tazobactam - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "(9925544), (3493236), 2158496, 2159863" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence, ECO:0000024 protein-binding evidence" strong "ampC (blaPDC) derepression occurs by the acquistion of mutations in its major regulators genes: ampD (10681322, 16251318, 16641450), dacB (19325877) and ampR (27736752, 29029112). Leads to acquired resistance" PSA0020 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core aztreonam - wildtype I MIC <= 16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0024 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0034 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core ceftazidime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0049 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms are needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0073 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core piperacillin - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0077 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core piperacillin-tazobactam - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0021 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core aztreonam - wildtype I MIC <= 16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0025 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0035 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core ceftazidime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0050 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms are needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0074 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core piperacillin - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0078 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core piperacillin-tazobactam - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0022 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core aztreonam - wildtype I MIC <= 16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0028 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0036 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core ceftazidime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0051 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0075 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core piperacillin - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0079 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core piperacillin-tazobactam - wildtype I MIC <=16 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong PSA0027 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) 11083635 ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)" PSA0026 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core cefepime - wildtype I MIC <= 8 mg/L EUCAST v14.0 (2024) 11083635 ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)" PSA0052 s__Pseudomonas aeruginosa crpP crpP - AEQ93536.1 - ARO:3004467 - Gene presence detected acquired ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) 34001507 ECO:0000005 enzymatic activity assay evidence strong CrpP Is Not a Fluoroquinolone-Inactivating Enzyme PSA0063 s__Pseudomonas aeruginosa crpP crpP - AEQ93536.1 - ARO:3004467 - Gene presence detected acquired levofloxacin - wildtype I MIC <=2 mg/L EUCAST v14.0 (2024) 34001507 ECO:0000005 enzymatic activity assay evidence strong CrpP Is Not a Fluoroquinolone-Inactivating Enzyme PSA0053 s__Pseudomonas aeruginosa mexE mexE - AAG05881.1 NF045904.1 ARO:3000803 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0054 s__Pseudomonas aeruginosa mexF - - AAG05882.1 - ARO:3000804 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0055 s__Pseudomonas aeruginosa oprN - - AAG05883.1 - ARO:3000805 - Gene presence detected core ciprofloxacin - wildtype I MIC <=0.5 mg/L EUCAST v14.0 (2024) 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0003 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core amoxicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, (3493236)" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0007 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core amoxicillin-clavulanic acid - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, (3493236), 2158496, 2159863" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence, ECO:0000024 protein-binding evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0011 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ampicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, (3493236)" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0015 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ampicillin-sulbactam - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, (3493236), 2159863" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence, ECO:0000024 protein-binding evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0029 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core cefotaxime - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, 3493236" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0039 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ceftriaxone - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "9925544, (3493236)" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong "ampC (blaPDC) expression is inducible by certain _-lactams (especially cefoxitin (3149885) and imipenem (3929679)), induction requires a functional AmpR (9118225). " PSA0004 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core amoxicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0008 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core amoxicillin-clavulanic acid - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0012 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core ampicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0016 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core ampicillin-sulbactam - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0030 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core cefotaxime - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0041 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0056 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core ertapenem - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0069 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core norfloxacin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0080 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core sulfamethoxazole - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0084 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core tetracycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0092 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0005 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core amoxicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0009 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core amoxicillin-clavulanic acid - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0013 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core ampicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0017 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core ampicillin-sulbactam - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0031 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core cefotaxime - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0042 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0057 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core ertapenem - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0070 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core norfloxacin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0081 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core sulfamethoxazole - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0085 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core tetracycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0093 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0006 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core amoxicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0010 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core amoxicillin-clavulanic acid - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0014 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core ampicillin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0018 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core ampicillin-sulbactam - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0032 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core cefotaxime - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0045 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0058 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core ertapenem - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0071 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core norfloxacin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0082 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core sulfamethoxazole - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0083 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core tetracycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0094 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "8226684, 8540696, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong All components of the efflux-pump system need to be functional (MexA-MexB-OprM) PSA0060 s__Pseudomonas aeruginosa aph(3')-IIb aph(3')-IIb WP_003113011.1 AGY72832.1 - ARO:3002645 - Gene presence detected core kanamycin A - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "6307974, 14638496" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence, ECO:0000005 enzymatic activity assay evidence" strong PSA0068 s__Pseudomonas aeruginosa aph(3')-IIb aph(3')-IIb WP_003113011.1 AGY72832.1 - ARO:3002645 - Gene presence detected core neomycin - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "6307974, 14638496" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence, ECO:0000005 enzymatic activity assay evidence" strong PSA0040 s__Pseudomonas aeruginosa catB7 catB7 WP_003112709.1 AAD02068.1 - ARO:3002679 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 10361706 ECO:0000005 enzymatic activity assay evidence weak lacks evidence of the degree to which MIC is affected "Species has expected resistance to chloramphenicol, and catB7 has demonstrated activity as a chloramphenicol acetyltransferase. However knockout mutants suggest the driver of clinical resistance is efflux via MexAB pump and the presence of catB7 in the absence of MexAB is unlikely to confer clinical resistance." PSA0044 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "11083635, 12483565" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" weak lacks evidence of the degree to which MIC is affected "MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY). Species has expected resistance to chloramphenicol, and MexXY has demonstrated activity for chloramphenicol. However knockout mutants suggest the driver of clinical resistance is efflux via MexAB pump and the presence of MexXY in the absence of MexAB is unlikely to confer clinical resistance." PSA0062 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core kanamycin A - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "10543738, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0087 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core tetracycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "10543738, 10952562, 11083635, 12483565" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0089 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core tigecycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 12604529 ECO:0001091 knockout phenotypic evidence strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0043 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "11083635, 12483565" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" weak lacks evidence of the degree to which MIC is affected "MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY). Species has expected resistance to chloramphenicol, and MexXY has demonstrated activity for chloramphenicol. However knockout mutants suggest the driver of clinical resistance is efflux via MexAB pump and the presence of MexXY in the absence of MexAB is unlikely to confer clinical resistance." PSA0061 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core kanamycin A - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "10543738, 11083635, 12483565" ECO:0001091 knockout phenotypic evidence strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0086 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core tetracycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" "10543738, 10952562, 11083635, 12483565" "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0088 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core tigecycline - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 12604529 ECO:0001091 knockout phenotypic evidence strong MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY) PSA0046 s__Pseudomonas aeruginosa mexE mexE - AAG05881.1 NF045904.1 ARO:3000803 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" weak lacks evidence of the degree to which MIC is affected MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators. All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0095 s__Pseudomonas aeruginosa mexE mexE - AAG05881.1 NF045904.1 ARO:3000803 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0047 s__Pseudomonas aeruginosa mexF - - AAG05882.1 - ARO:3000804 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" weak lacks evidence of the degree to which MIC is affected MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators. All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0096 s__Pseudomonas aeruginosa mexF - - AAG05882.1 - ARO:3000804 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0048 s__Pseudomonas aeruginosa oprN - - AAG05883.1 - ARO:3000805 - Gene presence detected core chloramphenicol - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" weak lacks evidence of the degree to which MIC is affected MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators. All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0097 s__Pseudomonas aeruginosa oprN - - AAG05883.1 - ARO:3000805 - Gene presence detected core trimethoprim - wildtype R not applicable "Expected resistant phenotypes v1.2 (13 January, 2023)" 9044268 "ECO:0001091 knockout phenotypic evidence, ECO:0000012 functional complementation evidence" strong MexEF-OprN overexpression contributes to increased MICs to this antibiotic. MexEF overexpression occurs by the acquistion of mutations in its regulators All components of the efflux-pump system need to be functional (MexE-MexF-OprN). PSA0037 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ceftazidime-avibactam - wildtype S MIC <= 8 mg/L EUCAST v14.0 (2024) "9925544, 3493236" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence" strong Mutations in the omega loop region of AmpC (specific blaPDC alleles) are associated with acquisition of resistance to the BL-BLI combinations ceftolozane-tazobactam and ceftazidime-avibactam. PSA0038 s__Pseudomonas aeruginosa blaPDC_gen blaPDC_gen - - - ARO:3000098 - Gene presence detected core ceftolozane-tazobactam - wildtype S MIC <= 4 mg/L EUCAST v14.0 (2024) "(9925544), (3493236), 2158496, 2159863" "ECO:0001091 knockout phenotypic evidence, ECO:0000005 enzymatic activity assay evidence, ECO:0000024 protein-binding evidence" strong Mutations in the omega loop region of AmpC (specific blaPDC alleles) are associated with the acqusition of resistance to the BL-BLI combinations ceftolozane-tazobactam and ceftazidime-avibactam. PSA0059 s__Pseudomonas aeruginosa fosA_PA1129 fosA_PA1129 - - NF000094.1 ARO:3000149 - Gene presence detected core fosfomycin - wildtype S MIC <= 256 mg/L ECOFF (January 2024) 28851843 ECO:0000012 functional complementation evidence strong PSA0065 s__Pseudomonas aeruginosa mexA mexA - AAA74436.1 NF033834.1 ARO:3000377 - Gene presence detected core meropenem - wildtype S MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0066 s__Pseudomonas aeruginosa mexB - - AAA74437.1 - ARO:3000378 - Gene presence detected core meropenem - wildtype S MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms are needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0067 s__Pseudomonas aeruginosa oprM - WP_003084633.1 AAG03816.1 - ARO:3000379 - Gene presence detected core meropenem - wildtype S MIC <= 8 mg/L EUCAST v14.0 (2024) "8540696, 11083635, 12483565, 9925544" ECO:0001091 knockout phenotypic evidence strong "MexAB-OprM overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms are needed to reach clinical resistance. MexAB-OprM overexpression occurs by the acquistion of mutations in its major regulators genes: mexR (8878574), nalC ( 15387820) and nalD (15855496). " PSA0064 s__Pseudomonas aeruginosa blaOXA-50_fam blaOXA-50_fam - - NF000432.2 ARO:3001796 - Gene presence detected core meropenem - wildtype S MIC <= 8 mg/L EUCAST v14.0 (2024) "15155197, 26621621 " ECO:0000012 functional complementation evidence strong "blaOXA-50 is a chromosomally encoded _-lactamase, also known as PoxB. Increases carbapenem MICs when overexpressed in vitro, but contribution to intrinsic resistance, if any, is marginal" PSA0002 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core amikacin - wildtype S MIC <= 16 mg/L EUCAST v14.0 (2024) 11083635 ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)" PSA0091 s__Pseudomonas aeruginosa mexY - - BAA34300.1 - ARO:3003033 - Gene presence detected core tobramycin - wildtype S MIC <= 2 mg/L EUCAST v14.0 (2024) "10543738, 11083635" ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)" PSA0001 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core amikacin - wildtype S MIC <= 16 mg/L EUCAST v14.0 (2024) 11083635 ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)" PSA0090 s__Pseudomonas aeruginosa mexX mexX - BAA34299.1 - ARO:3003034 - Gene presence detected core tobramycin - wildtype S MIC <= 2 mg/L EUCAST v14.0 (2024) "10543738, 11083635" ECO:0001091 knockout phenotypic evidence strong "MexXY overexpression contributes to increased MICs to this antibiotic but additional resistance mechanisms might be needed to reach clinical resistance. MexXY overexpression occurs by the acquistion of mutations in its major regulator gene mexZ (15336398) or within ParRS (21149619). MexXY requires a functional OprM (9925549). All components of the efflux-pump system need to be functional (MexX-MexY)"